Drew Endy


Work and research


En savoir plusStanford University, Dpt of Bioengineering


The immediate goal of our research is to enable the engineering of genetically encoded memory systems. Modest amounts of programmable memory, if implemented within living organisms, would have profound impacts on the study and treatment of diseases and would broadly enable non-medical applications of biotechnology. We are interested in both the basic and applied aspects of the problem, from considering how to best store information inside cells to practical applications. Our overall long term goal is to help make biology easy to engineer, an area of research known as synthetic biology.
 

En savoir plusEndy lab

Genetic Data Storage

We are focused on the development of engineered DNA systems that are capable of data storage inside living cells. Our recent work has focused on non-volatile recombinase addressable data (RAD) storage engineered from serine recombinases that target reversibly-invertible chromosomal data registers. We are interested in scaling genetically-encoded data systems from from a few bits to a few bytes.

Engineering Biology

Our overall long term goal is to help make biology easy to engineer, an area of research sometimes known as synthetic biology. In particular, we adapt ideas from metrology that help enable the distributed measurement and representation of in vivo molecular activities. We also develop genetic layout architectures that help establish reliably reusable standard biological parts supporting abstraction of biological functions.

Research Background & Context, Additional Materials

The many and diverse dissertations from past students in the lab, their peer-reviewed published articles, and our written perspectives and other published projects are all freely available online. We hope that students who are interested in exploring and taking forward their own research projects in the lab will be informed and inspired by the curiosity and independence of past student's work. We hope that others who are interested in understanding, contributing to, or constructively criticizing the lab's work make full use of our published record.


En savoir plusSynberc

Group "Practices" with Pamela Silver and Georges Church

"
We are working with all Synberc researchers and partners to advance the practice of synthetic biology responsibly, to the benefit of all people and the planet. From summer high school students to principal investigators, along with industry and government partners, we envision that each member of the Synberc community can help consider and develop leading examples of responsible synthetic biology in practice.  Specifically, the Practices Thrust has the following goals :

1. Biological Safety and Security: Develop learning materials that enable the next generation of biological engineers – the second biotechnology generation – to engage with, improve, and lead best practices with respect to research and laboratory biological safety. Also, implement a Synberc biological safety program to ensure that all Synberc research and researchers uphold best practices with respect to biological safety.  Lastly, partner with law enforcement and other relevant professionals, as needed, to advance policies and interactions promoting biological security.

2. Beyond Containment: Enable dialog between regulators, policy makers, and researchers that leads to shared understanding of needs and requirements regarding the engineering of microbes for release beyond controlled laboratory environments.  Identify opportunities for synthetic biology-enabled research that could improve best available technologies for mitigating or managing risks associated with environmental deployment of engineered microbes (e.g., in an open pond, or within a human patient).

3. Ownership, Sharing, and Innovation:  Establish working knowledge of the enabling technologies used by practitioners of synthetic biology.  Conduct basic and applied research on exploring how property rights specific to enabling technologies might best be organized to support the advancement of synthetic biology.  Importantly, carry out such work in a way that improves opportunities for long term Synberc sustainability and increases potential funding for the broader academic and commercial synthetic biology research communities.

4. Community and Leadership: Foster and support a diverse community of scholars and practitioners who are working together to best advance synthetic biology. Identify and constructively bring forward existing or emerging gaps, needs, or issues regarding the responsible practice of synthetic biology.  Connect with relevant partners to advance consideration of current and future needs and opportunities for synthetic biology."


Publications




Contact

Drew Endy, Stanford Bioengineering
Y2E2-269B, MC4201
473 Via Ortega
Stanford, CA 94305
(650) 723-7027 (c/o Jean Cookinham)

endy@stanford.edu