George Church


Work and research


En savoir plusHarvard Medical School, Dpt of Genetics

"Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses."


En savoir plusSynberc (Synthetic biology engineering research center)

Synberc is a multi-university research center established in 2006 with a grant from the National Science Foundation (NSF) to help lay the foundation for synthetic biology. Its mission is 1) to develop the basic knowledge and tools so we can design and assemble biological systems to accomplish many complex tasks; 2) to train a new cadre of researchers who will specialize in synthetic biology; and 3) to develop and share best practices for the safe and ethical development of the field.

Research group "Practices"
Leader : Drew Endy
Other participant : Pamela Silver
 
"We are working with all Synberc researchers and partners to advance the practice of synthetic biology responsibly, to the benefit of all people and the planet. From summer high school students to principal investigators, along with industry and government partners, we envision that each member of the Synberc community can help consider and develop leading examples of responsible synthetic biology in practice."

Publications

Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013) RNA-guided human genome engineering via Cas9. Science 339(6121):823-6.

Jewett MC, Fritz BR, Timmerman LE, Church GM (2013) In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation. Mol Syst Biol. 9:678

Alivisatos AP, Chun M, Church GM, Deisseroth K, Donoghue JP, Greenspan RJ, McEuen PL, Roukes ML, Sejnowski TJ, Weiss PS, Yuste R. (2013) The brain activity map. Science 339(6125):1284-5.

Ball MP, et al. (2012) A public resource facilitating clinical use of genomes. Proc Natl Acad Sci USA. 109(30):11920-7


  • For a complete listing of publications click here


Contact

Harvard Medical School
New Research Building, Room 238

77 Avenue Louis Pasteur
Boston, MA 02115

Tel: 617-432-7562
Fax: 617-432-6513