Ron Weiss






Work and research focus

En savoir plus MIT - Dpt of biological engineering

Synthetic biology. Construction and analysis of synthetic gene networks. Use of computer engineering principles of abstraction, composition, and interface specifications to program cells with sensors and actuators precisely controlled by analog and digital logic circuitry. Emphasis on establishing the engineering foundation for synthetic biology and the pursuit of novel applications enabled by the technology (e.g. programmed tissue engineering, diabetes, engineered neuronal circuits).


En savoir plusMIT - Dept of Electronical engineering and computer science

Synthetic biology. Construction and analysis of synthetic gene networks. Use of computer engineering principles of abstraction, composition, and interface specifications to program cells with sensors and actuators precisely controlled by analog and digital logic circuitry. Emphasis on establishing the engineering foundation for synthetic biology and the pursuit of novel applications enabled by the technology (e.g. programmed tissue engineering, diabetes, engineered neuronal circuits).

 
En savoir plusWeiss Lab for synthetic biology

Engineering celles, Builiding circuits.

Cells sense their environment, process information, and continuously react to both internal and external stimuli. The construction of synthetic gene networks can help improve our understanding of such naturally existing regulatory functions within cells. Synthetic gene networks will also enable a wide range of new programmed cells applications. We use computer engineering principles of abstraction, composition, and interface specifications to program cells with sensors and actuators precisely controlled by analog and digital logic circuitry. Here, recombinant DNA-binding proteins represent signals, and recombinant genes perform the computation by regulating protein expression. We constructed synthetic gene networks that implement biochemical logic circuits in Escherichia coli fabricated using the AND, NOT, and IMPLIES logic gates. We have built a variety of circuits, including a transcriptional cascade whose digital behavior improves significantly with the addition of genetic components. We have also built analog circuits that perform signal processing to detect specific chemical gradients and generate pulses in response to cell-cell communication. The integration of digital and analog circuitry is useful for controlling the behavior of individual cells and we have also combined these circuits with engineered cell-cell communication to coordinate the behavior of cell aggregates.


En savoir plusSynberc's biosafety program

"We have implemented an internal biological safety reporting program by which Synberc researchers declare the expected biosafety level of Synberc supported projects during the annual project proposal phase. Synberc supported projects also include declarations of each project’s institutional protocol approval. Importantly, we are relying on each Synberc institution’s existing biological safety review process to provide local biosafety assessment as required.  

Our efforts in this regard follow the framing provided by the US Recombinant DNA Advisory Committee in which local biosafety review boards, which include both technical experts as well as representatives of the public, should have immediate responsibility for considering issues of safety associated with biotechnology research.  Two Synberc investigators - Ron Weiss of MIT and Drew Endy of Stanford - served as ad hoc members of the Federal Recombinant DNA Advisory Committee to ensure that the new guidelines were comprehensive and practical; we note that these new guidelines finally go into effect March 2013."
 









Publications


Ron Weiss's complete list of publications

Contact

Massachusetts Institute of Technology - Department of Biological Engineering
Cambridge, MA 02139
Office: NE47-223

Phone 1: (617) 253-8966
Phone 2: +1 (617) 715-4150
E-mail: rweiss@mit.edu

Administrative Assistant: Olga Parkin
Office: NE47-257
Phone: (617) 452-2631

Home page : http://people.csail.mit.edu/rweiss/